http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_head
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://www.nanopub.org/nschema#hasAssertion
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_assertion
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://www.nanopub.org/nschema#hasProvenance
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_provenance
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://www.nanopub.org/nschema#hasPublicationInfo
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_publicationInfo
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.nanopub.org/nschema#Nanopublication
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_assertion
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.nanopub.org/nschema#Assertion
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_provenance
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.nanopub.org/nschema#Provenance
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_publicationInfo
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.nanopub.org/nschema#PublicationInfo
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_assertion
http://identifiers.org/ncbigene/6774
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612
http://linkedlifedata.com/resource/umls/id/C0024291
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057
http://rdf.disgenet.org/resource/gda/DGNc416afe5307e4a951ce1d6d7bb23f7bc
http://semanticscience.org/resource/SIO_000628
http://identifiers.org/ncbigene/6774
http://rdf.disgenet.org/resource/gda/DGNc416afe5307e4a951ce1d6d7bb23f7bc
http://semanticscience.org/resource/SIO_000628
http://linkedlifedata.com/resource/umls/id/C0024291
http://rdf.disgenet.org/resource/gda/DGNc416afe5307e4a951ce1d6d7bb23f7bc
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://semanticscience.org/resource/SIO_001121
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_provenance
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_assertion
http://purl.org/dc/terms/description
[Our results indicated that (1) the expression of TEL-FGFR3 but not DeltaHLH-TEL-FGFR3 resulted in efficient focus formation in NIH/3T3 cells and conferred interleukin 3 independence to Ba/F3 cells by a constitutive tyrosine kinase activity probably through oligomerization by the HLH domain of TEL; (2) although effector proteins including classical mitogen-activated protein kinase (MAPK), p38 MAPK, phosphatidylinositol 3-kinase (PI3-K), mammalian target or rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT-3) and STAT-5 were activated in TEL-FGFR3 transformants, the growth of the transformants was inhibited by SU5402 (concentration that inhibits 50% [IC5)]=5 microM) and the PI3-K inhibitor, LY294002 (IC5)=10 microM) and wortmannin (IC50=5 microM), but not by U0126, SB203580, or rapamycin; and (3) injection of TEL-FGFR3 transformants induced lethal leukemia into syngeneic mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_assertion
http://purl.org/ontology/wi/core#evidence
http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_assertion
http://semanticscience.org/resource/SIO_000772
http://identifiers.org/pubmed/15514005
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_assertion
http://www.w3.org/ns/prov#wasDerivedFrom
http://rdf.disgenet.org/v4.0.0/void/befree-2016
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_assertion
http://www.w3.org/ns/prov#wasGeneratedBy
http://purl.obolibrary.org/obo/ECO_0000203
http://rdf.disgenet.org/v4.0.0/void/befree-2016
http://purl.org/pav/importedOn
2016-02-19
http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://purl.obolibrary.org/obo/ECO_0000212
http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature
http://www.w3.org/2000/01/rdf-schema#comment
Gene-disease associations inferred from text-mining the literature.
http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature
http://www.w3.org/2000/01/rdf-schema#label
DisGeNET evidence - LITERATURE
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps130_publicationInfo
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/dc/terms/created
2016-05-13T12:45:16+02:00
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/dc/terms/rights
http://opendatacommons.org/licenses/odbl/1.0/
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/dc/terms/rightsHolder
http://rdf.disgenet.org/v4.0.0/void/IBIGroup
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/dc/terms/subject
http://semanticscience.org/resource/SIO_000983
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/net/provenance/ns#usedData
http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/pav/authoredBy
http://orcid.org/0000-0001-5999-6269
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/pav/authoredBy
http://orcid.org/0000-0002-7534-7661
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/pav/authoredBy
http://orcid.org/0000-0002-9383-528X
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/pav/authoredBy
http://orcid.org/0000-0003-0169-8159
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/pav/authoredBy
http://orcid.org/0000-0003-1244-7654
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/pav/createdBy
http://orcid.org/0000-0003-0169-8159
http://rdf.disgenet.org/resource/nanopub/NP466491.RAQnMfJztZV28L7Sie8Zu4b0MfbTWwYw-yNSxTHNQcwps
http://purl.org/pav/version
v4.0.0.0
http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf
http://purl.org/pav/version
v4.0.0