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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#_5 http://www.w3.org/ns/prov#value TSC2 S1798A mutant.Thi s mutant was used to prove that RSK-dependent phosphorylation of tuberin on Ser1798 inhibits its potential to turn off Rheb and to downregulate the activities of mTOR and p70S6K.Mu tation of Ser1798 inhibited most of tuberin phosphorylation and inactivation by RSK (Roux et al., 2004).Invest igating PARP cleavage, caspase 3 cleavage, the percentage of HOPI-positive cells and the percentage of subG1 cells demonstrated that the cell survival effects of activated Ras over tuberin-induced apoptosis are significantly diminished by this mutation in TSC2 (Figures 5a–c). http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17922028 http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17922028 http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#_5 http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM http://purl.org/dc/terms/created 2014-07-03T14:33:13.218+02:00 http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAQdrlnmFaTan2umZab8ukS5qvTDJ_BudRxNiZ54fzCpM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234