@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAQVM8YXOcJt2e9stzq8mxEQXdxa5tWeNpIrwqsVOIRyM> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAQVM8YXOcJt2e9stzq8mxEQXdxa5tWeNpIrwqsVOIRyM#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: mgi:99928;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0003824 .
  
  sub:_4 geneProductOf: mgi:96550;
    a Protein: .
  
  sub:_5 hasAgent: sub:_6;
    a go:0042789 .
  
  sub:_6 geneProductOf: mgi:103035;
    a Protein: .
  
  sub:_7 rdf:object sub:_5;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_3;
    a rdf:Statement .
  
  sub:_8 occursIn: species:10090;
    rdf:object sub:_7;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "cat(p(MGI:Il2rb)) => tscript(p(MGI:Stat5b))", "kin(p(MGI:Jak3)) => (cat(p(MGI:Il2rb)) => tscript(p(MGI:Stat5b)))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_10;
    pav:version "20131211" .
  
  sub:_10 rdfs:label "Selventa" .
  
  sub:_9 prov:value "Stat5 proteins activated by IL-2.  The phosphorylated tyrosines on IL-2Rbeta can then serve as docking sites for signaling molecules that otherwise cannot associate with IL-2Rbeta, including the adaptor protein Shc, Stat5a, and Stat5b (Figure 2).  For example, only phosphorylated (but not non-phosphorylated) peptides spanning either Tyr-392 or Tyr-510 of IL-2Rbeta can efficiently compete with IL-2-induced Stat5 DNA binding to a GAS motif  IL-2-mediated hetero-dimerization of its receptor triggers a rapid increase in the recruitment of Jak3 and activation of both Jak1 and Jak3 (Johnston et al., 1994; Witthuhn et al., 1994). These kinases phosphorylate the receptor as well as each other, and activate other signaling molecules associated with the receptor. The phosphorylated tyrosines on IL-2Rbeta can then serve as docking sites for signaling molecules that otherwise cannot associate with IL-2Rbeta, including the adaptor protein Shc, Stat5a, and Stat5b";
    prov:wasQuotedFrom pubmed:10851055 .
  
  sub:assertion prov:hadPrimarySource pubmed:10851055;
    prov:wasDerivedFrom beldoc:, sub:_9 .
}

sub:pubinfo {
  this: dcterms:created "2014-07-03T14:31:35.798+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}