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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#_5 http://www.w3.org/ns/prov#value Here, we show that Lmx1b(-/-) podocytes have reduced numbers of foot processes, are dysplastic, and lack typical slit diaphragms, indicating an arrest in development. Using antibodies to podocyte proteins important for podocyte function, we found that Lmx1b(-/-) podocytes express near-normal levels of nephrin, synaptopodin, ZO-1, alpha3 integrin, and GBM laminins. However, mRNA and protein levels for CD2AP and podocin were greatly reduced, suggesting a cooperative role for these molecules in foot process and slit diaphragm formation. We identified several LMX1B binding sites in the putative regulatory regions of both CD2AP and NPHS2 (podocin) and demonstrated that LMX1B binds to these sequences in vitro and can activate transcription through them in cotransfection assays. http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11956244 http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11956244 http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#_5 http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4 http://purl.org/dc/terms/created 2014-07-03T14:31:48.468+02:00 http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAQDsEIvM0Kw_IAhc7ES_WRqqaPkbRrn1R6x_SxnJDmz4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234