http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#Head http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#assertion http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#provenance http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#assertion http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_2 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_2 http://purl.obolibrary.org/obo/RO_0002204 http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=2868 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_3 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_4 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_4 http://purl.obolibrary.org/obo/RO_0002204 http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=2081 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_5 http://www.selventa.com/vocabulary/variantOf http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1309196 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_5 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_3 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_7 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000540 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_7 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_6 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_1 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#assertion http://www.w3.org/2000/01/rdf-schema#label cat(p(RGD:Igf1)) -> (kin(p(RGD:Akt1)) => p(RGD:Foxo3,pmod(P,T,32))) http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(RGD:Akt1)) => p(RGD:Foxo3,pmod(P,T,32)) http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_9 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_8 http://www.w3.org/ns/prov#value IGF-1 rapidly induced the phosphorylation of Akt and FKHRL1 in PC12 cells. The phosphorylation of Akt and FKHRL1 induced by 10 nm IGF-1 was inhibited by the phosphatidylinositide 3-kinase (PI3K) inhibitors wortmannin (0.25-2 microm) and LY294002 (12.5-100 microm), but not by the MEK inhibitor PD98059 (50 microm) or the p70 S6 kinase pathway inhibitor rapamycin (50 nm), suggesting that the phosphorylation of FKHRL1 induced by IGF-1 is mediated by the PI3K pathway. As observed for IGF-1, an in vitro kinase assay with purified active Akt kinase demonstrated that the kinase is capable of directly phosphorylating FKHRL1 at Thr(32) and Ser(253) http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_8 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10995739 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_9 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10995739 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#_8 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs#pubinfo http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs http://purl.org/dc/terms/created 2014-07-03T14:31:37.230+02:00 http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAQB7dyYkhExw8pjEdTtwRfs_G60Wk744jrLfXqGhBfLs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234