. . . . . . . . . . . . . . . . . . "complex(a(SCHEM:Sirolimus),p(HGNC:FKBP1A)) =| cat(p(HGNC:FKBP1A))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "TSC2 was found to bind to Rheb-GTP in vitro and to reduce Rheb GTP levels in vivo. Over-expression of Rheb but not Rap1 promoted the activation of S6 kinase in a rapamycin-dependent manner, suggesting that Rheb acts upstream of mTOR. The ability of Rheb to induce S6 phosphorylation was also inhibited by a farnesyl transferase inhibitor, suggesting that Rheb may be responsible for the Ras-independent anti-neoplastic properties of this drug." . . "Selventa" . . . . "2014-07-03T14:32:04.171+02:00"^^ . . .