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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAQ1eXwaxMulN0gyuujYY889sBWul4mKOZVtCNWcu45-k#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAQ1eXwaxMulN0gyuujYY889sBWul4mKOZVtCNWcu45-k#_4 http://www.w3.org/ns/prov#value Extensive oxidative and/or nitrosative stress triggers the third pathway by inducing extensive DNA breakage, overactivation of PARP, and consequent depletion of the cellular stores of its substrate NAD+, impairing glycolysis, Krebs cycle, and mitochondrial electron transport, and eventually resulting in ATP depletion and consequent cell dysfunction and death by necrosis. 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