. . . . . . . . . . . . . . . . . . . . "a(CHEBI:nicotine) -> complex(p(HGNC:RAF1),p(HGNC:RB1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "As shown in Figure 2A, quiescent A549 cells and HAECs did not have any detectable Rb–Raf-1 interaction, but stimulation with nicotine induced a robust Rb–Raf-1 interaction. The Rb–Raf-1 interaction was detected up to 2 hours after nicotine stimulation and dissipated within 4 hours. The binding between Rb and Raf-1 was also observed in lung cancer cell lines H23, H441, and H226 (Figure 2B) as well as in primary lung cells such as SAECs, NHBEs, and HMEC-Ls stimulated with 1 ?M nicotine (Figure 2C). Nicotine-induced Rb–Raf-1 interaction was abolished by ?-bungarotoxin and MAA, suggesting a role for ?7-nAChR in this binding (Figure 2D)." . . "Selventa" . . . . "2014-07-03T14:33:02.269+02:00"^^ . . .