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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#_6 http://www.w3.org/ns/prov#value Because LPS stimulation upregulates CD14 and TLR4 expression, it was necessary to control for the possibility that these newly expressed molecules were associated with one another independent of LPS stimulation. Although the calcium ionophore A23187 increased the expression of CD14 and TLR4, they did not exhibit energy transfer. However, following A23187 treatment, LPS promoted physical proximity between CD14 and TLR4. Therefore, we suggest that a close interaction between CD14 and TLR4 participates in LPS signaling, leading to nuclear translocation of NF-kappaB. http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11034352 http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11034352 http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#_6 http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE http://purl.org/dc/terms/created 2014-07-03T14:31:37.602+02:00 http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAPv97hG0tZyvshU_79u17POnGtoVlq7ZLA5ikv067KOE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234