http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#Head http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#assertion http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#provenance http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#assertion http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:104564 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_3 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:104772 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_2 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyDecreases http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_1 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Cdkn1c) =| kin(p(MGI:Cdk2)) http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_5 http://www.w3.org/ns/prov#value Site-directed mutagenesis identified phenylalanine 79 and tyrosine 80 within the 3(10) helix region of p57 as crucial residues for kinase inhibition, supporting the structural evidence that the 3(10) helix binds deep inside the catalytic cleft of Cdk2, mimicking ATP. Mutations within the 3(10) helix region of the p57 molecule completely abolished the ability to arrest the cell cycle at G1 in vivo. These results indicate that this region is specifically utilized by p57 in selectively inhibiting cyclin A or E/Cdk2+ activities. Thus the 3(10) helix motif may confer a specific regulatory mechanism by which p57 differentially regulates Cdk2 and Cdk4 activities. http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9632724 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9632724 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#_5 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg http://purl.org/dc/terms/created 2014-07-03T14:30:59.997+02:00 http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAPp-68mId_1TOigFrGzRx52MRA-SY4QUWYguO8-UqZEg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234