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[Given previous evidence that certain susceptibility loci and carcinogens are associated with characteristic mutations, or `signatures` in other cancers, we hypothesized that the characteristic somatic mutations in the KIT and PDGFRA genes in GIST tumors may similarly be mutational signatures that are causally linked to specific mutagens or susceptibility loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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