sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_8 ;
    pav:version "20131211" .
  sub:_6 dce:identifier "OMIM text for CREM" ;
    dce:title "OMIM text for CREM" ;
    dce:type "Online Resource" .
  sub:_7 prov:value "Molina et al. (1993) identified a splice variant of CREM that is induced by activation of the adenylyl cyclase signal transduction pathway. This isoform, which they called 'inducible cAMP early repressor' (ICER), is generated by induction of an internal promoter. Because ICER contains the DNA-binding domain without the transactivation domain of other CREM variants, it serves as a dominant-negative repressor of cAMP-induced transcription. They demonstrated that ICER is rapidly upregulated by stimulation of the beta- adrenergic receptor in cardiac myocytes and works as a negative regulator of hypertrophy as well as a positive mediator of apoptosis." ;
    prov:wasQuotedFrom sub:_6 .
  sub:_8 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource sub:_6 ;
    prov:wasDerivedFrom beldoc: , sub:_7 .
}