sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_5 ; pav:version "20131211" . sub:_4prov:value "The relationship between NOX-mediated oxidant signaling and tyrosine phosphorylation was first indicated by pioneering studies by Finkel and Rhee and their co-workers (39,40), who demonstrated that the activation of receptor tyrosine kinases by growth factors, such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF), is associated with transient and regulated cellular production of H2O2, which amplifies tyrosine kinase signaling by temporally inactivating a protein tyrosine phosphatase (PTP)." ; prov:wasQuotedFrompubmed:18164271 . sub:_5rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:18164271 ; prov:wasDerivedFrombeldoc: , sub:_4 . }