. . . . . . . "[These results suggest reciprocal feedback influences between tPA, PAI-1 and A? during aging and amyloid pathogenesis in AD brain; tPA-mediated plasmin activity is declined throughout the brain causing A? deposition during aging, and the A? deposits locally attract the cluster of tPA and/or PAI-1 around their deposits to competitively determine tPA/plasmin-mediated A? proteolysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:19:27+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .