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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAPQ_1mCFjA9I-N4zIDS--xAa6RkK5wBFQPxyle8LkmFw#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAPQ_1mCFjA9I-N4zIDS--xAa6RkK5wBFQPxyle8LkmFw#_4 http://www.w3.org/ns/prov#value ranscriptional response of selected cellular genes in Jurkat T cells upon SDF-1 exposure. Among the genes which showed a continuous increase in their expression following SDF-1 exposure were those involved in detoxification, DNA repair, apoptosis, TCR signal transduction, cytokinesis, cell adhesion molecules, chemokine receptors, and IFN-related molecules. The effects of MEK and PI3K inhibitors (50 µM PD098059 (20 21 ) and 20 µM LY294002 (22 ), respectively) on the expression of these genes are also shown. Jurkat cells were exposed to SDF-1 in the presence of the inhibitors for 6 h without FCS. Reference mRNA was obtained from cells exposed to the inhibitors but not to SDF-1. 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