sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_9 ; pav:version "20131211" . sub:_8prov:value "he CD28 signaling pathway primarily involves a small subset of signaling molecules that are also implicated in TCR signal transmission, in particular the phosphoinositide-3 kinase (PI3-K) pathway with downstream activation of AKT [32,33], and activation of TEC protein kinases and of interleukin-2-inducible T-cell kinases [27,34]. AKT activation cooperates with the TCR-induced activation of protein kinase C (PKC)? to activate the NF-?B pathway, which is otherwise only slightly activated by TCR alone. " ; prov:wasQuotedFrompubmed:19007423 . sub:_9rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:19007423 ; prov:wasDerivedFrombeldoc: , sub:_8 . }