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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#_4 http://www.w3.org/ns/prov#value Increased expression of PKC in malignant and aggressive breast cancers was recently demonstrated, and PKC activity has been shown to be higher in breast cancers than in normal breast tissue [68, 69]. In addition, high levels of PKC? and -? were correlated with enhanced uPA secretion in highly invasive MDA-MB- 231 breast cancer cells [70]. Furthermore, the introduction of PKC? gene to nonmetastatic MCF-7 breast cancer cells resulted in more aggressive neoplastic phenotype, and the stimulation of PKC activity with phorbol ester, phorbol-12- myristate-13-acetate (PMA), resulted in increases in both invasiveness and uPA expression http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15180498 http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15180498 http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#_4 http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4 http://purl.org/dc/terms/created 2014-07-03T14:30:23.973+02:00 http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAPDfrDAImV6QVkO7oy_bue4TQZddOurVX3-6hJGlp-f4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234