[ {
  "@graph" : [ {
    "@id" : "http://bio2rdf.org/drugbank:DB00543",
    "@type" : [ "http://bio2rdf.org/drugbank_vocabulary:Drug" ],
    "http://bio2rdf.org/bio2rdf_vocabulary:identifier" : [ {
      "@value" : "DB00543"
    } ],
    "http://bio2rdf.org/bio2rdf_vocabulary:namespace" : [ {
      "@value" : "drugbank"
    } ],
    "http://bio2rdf.org/bio2rdf_vocabulary:uri" : [ {
      "@value" : "http://bio2rdf.org/drugbank:DB00543"
    } ],
    "http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org" : [ {
      "@id" : "http://identifiers.org/drugbank/DB00543"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:drugbank-id" : [ {
      "@value" : "APRD00142"
    }, {
      "@value" : "DB00543"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-atc" : [ {
      "@id" : "http://bio2rdf.org/atc:N06AA17"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-bindingdb" : [ {
      "@id" : "http://bio2rdf.org/bindingdb:22870"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-cas" : [ {
      "@id" : "http://bio2rdf.org/cas:14028-44-5"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-chebi" : [ {
      "@id" : "http://bio2rdf.org/chebi:2675"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-chemspider" : [ {
      "@id" : "http://bio2rdf.org/chemspider:2085"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-dpd" : [ {
      "@id" : "http://bio2rdf.org/dpd:527106"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-gtp" : [ {
      "@id" : "http://bio2rdf.org/gtp:201"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-iuphar" : [ {
      "@id" : "http://bio2rdf.org/iuphar:201"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-kegg" : [ {
      "@id" : "http://bio2rdf.org/kegg:D00228"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-ndc" : [ {
      "@id" : "http://bio2rdf.org/ndc:0591-5713-01"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb" : [ {
      "@id" : "http://bio2rdf.org/pharmgkb:PA448405"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound" : [ {
      "@id" : "http://bio2rdf.org/pubchem.compound:2170"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance" : [ {
      "@id" : "http://bio2rdf.org/pubchem.substance:46509117"
    } ],
    "http://bio2rdf.org/drugbank_vocabulary:x-wikipedia" : [ {
      "@id" : "http://bio2rdf.org/wikipedia:Amoxapine"
    } ],
    "http://purl.org/dc/terms/description" : [ {
      "@language" : "en",
      "@value" : "Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amoxapine may be used to treat neurotic and reactive depressive disorders, endogenous and psychotic depression, and mixed symptoms of depression and anxiety or agitation."
    } ],
    "http://purl.org/dc/terms/identifier" : [ {
      "@value" : "drugbank:DB00543"
    } ],
    "http://purl.org/dc/terms/title" : [ {
      "@language" : "en",
      "@value" : "Amoxapine"
    } ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@language" : "en",
      "@value" : "Amoxapine [drugbank:DB00543]"
    } ],
    "http://www.w3.org/2000/01/rdf-schema#seeAlso" : [ {
      "@id" : "http://www.drugbank.ca/drugs/DB00543"
    }, {
      "@id" : "http://www.drugs.com/cdi/amoxapine.html"
    }, {
      "@id" : "http://www.rxlist.com/cgi/generic/amoxapine.htm"
    } ]
  } ],
  "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#publicationInfo"
    } ]
  } ],
  "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#head"
}, {
  "@graph" : [ {
    "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#assertion",
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz"
    } ]
  }, {
    "@id" : "http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3",
    "http://www.w3.org/ns/dcat#distribution" : [ {
      "@id" : "http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz"
    } ]
  }, {
    "@id" : "http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2015-01-09T17:00:50-05:00"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00"
    } ]
  }, {
    "@id" : "http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip",
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "http://drugbank.ca"
    } ]
  }, {
    "@id" : "http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00",
    "http://purl.org/pav/retrievedOn" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2014-11-12T07:57:03-05:00"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip"
    } ]
  } ],
  "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2018-03-30T11:11:16.377+02:00"
    } ],
    "http://purl.org/dc/terms/license" : [ {
      "@id" : "https://creativecommons.org/licenses/by-nc/4.0/"
    } ],
    "http://purl.org/nanopub/x/hasSignatureElement" : [ {
      "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#signature.MC0CFCGHr5FF3CUo"
    } ],
    "http://www.w3.org/ns/prov#wasGeneratedBy" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475"
    } ]
  }, {
    "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#signature.MC0CFCGHr5FF3CUo",
    "http://purl.org/nanopub/x/hasPublicKey" : [ {
      "@value" : "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"
    } ],
    "http://purl.org/nanopub/x/hasSignature" : [ {
      "@value" : "MC0CFCGHr5FF3CUojvd4jUKUB0TPQMPSAhUAkrfWAo60KQXIJ19vSALfaUrxenA="
    } ],
    "http://purl.org/nanopub/x/signedBy" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB"
    } ]
  }, {
    "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB",
    "http://www.w3.org/ns/prov#specializationOf" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub"
    } ],
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  }, {
    "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475",
    "http://purl.org/dc/terms/identifier" : [ {
      "@value" : "7720f136-841b-4851-a6e4-ad20a409a475"
    } ],
    "http://www.w3.org/ns/prov#used" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349"
    } ],
    "http://www.w3.org/ns/prov#wasAssociatedWith" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB"
    } ],
    "http://www.w3.org/ns/prov#wasStartedBy" : [ {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  }, {
    "@id" : "https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349",
    "http://purl.org/dc/terms/isVersionOf" : [ {
      "@id" : "https://github.com/tkuhn/bio2rdf2nanopub"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "eda7951a5f6c622c5d2132f50c3093138484a349"
    } ],
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  } ],
  "@id" : "http://bio2rdf.org/drugbank:DB00543_nanopub.RAPCnYAb-8PjiHaYT9BSi-6YPGFIk4XwQlazZCAZFUfnE#publicationInfo"
} ]