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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#_3 http://www.w3.org/ns/prov#value Through isolation and analysis of the SIVA promoter, we have identified response elements for both p53 and E2F1. Like p53, E2F1 is another tumor suppressor gene involved in the regulation of apoptosis, including neuronal injury models. We have identified E2F consensus sites in the promoter region, whereas p53 recognition sequences were found in intron1. Sequence analysis has shown that these consensus sites are also conserved between mouse and human SIVA genes. Electrophoretic mobility shift assays reveal that both transcription factors are capable of binding to putative consensus sites, and luciferase reporter assays reveal that E2F1 and p53 can activate transcription from the SIVA promoter. http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15105421 http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15105421 http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#_3 http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY http://purl.org/dc/terms/created 2014-07-03T14:30:22.772+02:00 http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAP8QIPugTdDP4Vvh5pa7CUKKlNfaUozgJmjM1HLgMXLY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234