. . . . . . . "[Since neither expression of wild-type nor mutant CALHM1 affected amyloid �-peptide (A�) production or A�-mediated cellular toxicity, we conclude that rare genetic variants in CALHM1 lead to Ca(2+) dysregulation and may contribute to the risk of EOAD through a mechanism independent from the classical A� cascade.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:19:12+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .