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[The positive predictive value of genotyping was low, but the likelihood ratio for developing either haematological or hepatotoxicity by identifying TPMT heterozygosity, was 9.75. In our patient population this translates into an improvement from a pre-test probability of developing haematological or hepatotoxicity of 11%, to a post-test level of 50%. Heterozygous patients may then be targeted for a more `tailored` increase in dosing and regular laboratory monitoring.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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