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[The substantial public health burden of HH as a common, deadly, detectable, and treatable chronic disease has led the College of American Pathologists to recommend that systematic screening for hemochromatosis is warranted for all persons over the age of 20 years. The recent discovery that most HH cases are the result of a single well-conserved homozygous missense mutation (C282Y) within a novel transferrin-receptor binding protein (HFE) has given rise to diagnostic clinical tests for the DNA-based detection of this pathologic mutation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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