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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#_5 http://www.w3.org/ns/prov#value In this study, using cDNA microarray analysis, we identified ATF5 as the candidate transcriptional repressor for SAP expression in LMP-1-expressing T cells. LMP-1 up-regulated ATF5 via TRAF2,5/NF-kappaB signals to suppress SAP gene expression. Reporter assays and electrophoretic mobility shift assays revealed that ATF5 bound differentially to two sites of the SAP promoter. In resting T cells, ATF5 bound predominantly to the high-affinity site in the -81 to -74 region while additionally binding to the low-affinity site at -305 to -296 in LMP-1-expressing T cells. Such binding subsequently disrupted the transcription of the SAP gene. At the same time, Th1 cytokine secretion was enhanced. This phenomenon was also observed in conditions such as ATF5 overexpression, phytohemagglutinin stimulation of primary T cells, and ligand engagement of T-cell lines. http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18832568 http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18832568 http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#_5 http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es#pubinfo http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es http://purl.org/dc/terms/created 2014-07-03T14:33:26.448+02:00 http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAOmqeOzxjqUoaOlp0-4NJOqW1r5WE7-Emh_BfSIsT5Es http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234