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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#_3 http://www.w3.org/ns/prov#value In this study, we used primary cultured rat and dog hepatocytes to investigate the underlying mechanisms of a novel PPAR alpha and -gamma coagonist, LY465608, relative to fenofibrate, a prototypical PPAR alpha agonist. Analysis of peroxisomal beta-oxidation gene expression markers by quantitative real-time PCR confirmed that PPAR agonists induced the peroxisomal enzymes, acyl-coenzyme A (CoA) oxidase (Acox), enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase (Ehhadh), and 3-ketoacyl-CoA thiolase (Acaa1) at the transcriptional level in rat hepatocytes, but not dog hepatocytes. Expression of mRNA for the mitochondrial beta-oxidation gene hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase (Hadhb), however, increased in both rat and dog hepatocytes, consistent with biochemical measurements of peroxisomal and mitochondrial beta-oxidation. http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17255113 http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17255113 http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#_3 http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4 http://purl.org/dc/terms/created 2014-07-03T14:33:08.272+02:00 http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAOgKJzjdYYODYnSnIXRWyFD00eUBd6yN5eHrKDsCS1-4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234