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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAOa64dH2VqUHH45udh9eIrmUGlKV6l8aZlxl44BFQjiM#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAOa64dH2VqUHH45udh9eIrmUGlKV6l8aZlxl44BFQjiM#_6 http://www.w3.org/ns/prov#value GDNF signaling needs heparan sulphate glycosaminoglycans, such as syndecans and glypicans, probably to ensure local concentration of GDNF [26]. GDNF is able to trigger intracellular signaling events that are mediated by GFR-a but not by RET [27]. Stimulated GFR-a can trigger c-Src activation; in turn, c-Src induces phosphorylation of Met, the tyrosine kinase receptor of hepatocyte growth factor (HGF) [28]. 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