@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAOSooRui77tdwvsDarx9pe5pI1_2OngdGOxbD006KNso> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAOSooRui77tdwvsDarx9pe5pI1_2OngdGOxbD006KNso#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix entrez: <http://www.ncbi.nlm.nih.gov/gene/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: entrez:20963;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0016301 .
  
  sub:_4 geneProductOf: mgi:1346858;
    a Protein: .
  
  sub:_5 occursIn: obo:CL_0000235, species:10090;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "kin(p(EGID:20963)) -> kin(p(MGI:Mapk1))" .
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sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "20131211" .
  
  sub:_6 prov:value "TLR4 and Syk were required for mmLDL activation of guanine nucleotide exchanging factor Vav1, small GTPase Ras, kinases Raf, MEK1 and ERK1/2; in turn, ERK1/2 phosphorylated paxillin at Ser126 and activated small GTPases Cdc42, Rac and Rho (Figure 3 and Online Figure III). These signaling events lead to actin polymerization, a necessary step in membrane ruffling. Our results agree with the reports of Syk-dependent ERK1/2 activation in phagocytosis45, ERK1/2 activation in TLR4-dependent antigen uptake by dendritic cells46, and the role of paxillin and small GTPases in actin reorganization and pinocytic vesicle formation9,26,27,47. ";
    prov:wasQuotedFrom pubmed:19461045 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:19461045;
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}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:34.774+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}