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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAOK0inq7pDADdqkAW5LQBa_44IVjV5K8EwTTZHBvZM78#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAOK0inq7pDADdqkAW5LQBa_44IVjV5K8EwTTZHBvZM78#_4 http://www.w3.org/ns/prov#value Whereas the function of CKIs as tumour suppressors is well characterized in the nucleus, they also seem to function in the cytoplasm,where they regulate cytoskeletal functions. This occurs through the modulation of the Rho signalling pathway. This cytoplasmic function could be oncogenic, as inhibition of the Rho pathway can result in increased migratory capacity. Phosphorylation of p21 on Thr145 by protein kinase B (PKB)/Akt48 or Pim1 inhibits the nuclear localization of p21. 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