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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#_4 http://www.w3.org/ns/prov#value o this end, we tested the decoy ability of a novel peptide nucleic acid (PNA)-DNA chimera which carries a central DNA strand, containing Sp1-binding sequence, covalently linked to two PNA fragments at both ends (PNA-DNA-PNA, PDP). The chimera was synthesized, annealed with complementary DNA (PDP-DNA), and then tested for its ability to bind Sp1 both in vitro and in living MDA-MB-231 breast cancer cells in the presence of urokinase (uPA). This PDP-DNA decoy molecule efficiently competes for the binding to endogenous Sp1 in nuclear extracts, and upon transfection with liposomal vectors, causes a marked decrease of available Sp1 in both untreated and uPA-treated MDA-MB-231 cells. Accordingly, both uPA-dependent enhancement of uPAR expression and cell migration were strongly reduced in transfected cells. http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16143315 http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16143315 http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#_4 http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE http://purl.org/dc/terms/created 2014-07-03T14:32:49.775+02:00 http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAODOl8oO466KOuRfT8PJjUbKVVQpFQw5Boal1qv-0juE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234