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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#_5 http://www.w3.org/ns/prov#value CTCF is required for interactions between XL9 and HLA-DRB1 and HLA-DQA1 and for maximal histone modification of the promoter regions. CTCF was found to interact with XL9 by in vivo (chromatin immunoprecipitation [ChIP]) and in vitro (electrophoretic mobility shift assay) assays (14) (15). To test the hypothesis that CTCF plays a role in the regulation of the flanking MHC genes HLA-DRB1 and HLA-DQA1, siRNAs were used to knockdown the expression of CTCF.Assessment of HLA-DRB1 and HLA-DQA1 mRNA expression during the knockdown time course assays showed a marked reduction in steady-state mRNA levels of both HLA-DRB1 and HLA-DQA1 when siRNAs to CTCF but not GFP were used (Fig. 1 C). http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18347100 http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18347100 http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#_5 http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8 http://purl.org/dc/terms/created 2014-07-03T14:33:18.654+02:00 http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAODDsj47XzMAttfKO_MdEkwDphu1dkgfjBmKskTXdCQ8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234