http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_head http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_assertion http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_provenance http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_assertion http://identifiers.org/ncbigene/2099 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0006142 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/resource/gda/DGN90fec1df56851305adbee3989ad3e083 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/2099 http://rdf.disgenet.org/resource/gda/DGN90fec1df56851305adbee3989ad3e083 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0006142 http://rdf.disgenet.org/resource/gda/DGN90fec1df56851305adbee3989ad3e083 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_provenance http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_assertion http://purl.org/dc/terms/description [Our very recent assessment of the mechanisms by which cancer-associated increased lipogenesis and its inhibition alters the E2/ER signaling discovered that fatty acid synthase (FASN), the enzyme catalyzing the terminal steps in the de novo biosynthesis of long-chain fatty acids, differentially modulates the state of sensitivity of breast and endometrial cancer cells to E2-stimulated ER transcriptional activation and E2-dependent cell growth and survival: 1) pharmacological inhibition of FASN activity induced a dramatic augmentation of E2-stimulated ER-driven gene transcription, whereas interference (RNAi)-mediated silencing of FAS gene expression drastically lowered E2 requirements for optimal activation of ER transcriptional activation in breast cancer cells; conversely, pharmacological and RNAi-induced inhibition of FASN worked as an antagonist of E2- and tamoxifen-dependent ER transcriptional activity in endometrial adenocarcinoma cells; 2) pharmacological and RNAi-induced inhibition of FASN synergistically enhanced E2-mediated down-regulation of ER protein and mRNA expression in breast cancer cells, whereas specific FASN blockade resulted in a marked down-regulation of E2-stimulated ER expression in endometrial cancer cells; and 3) FASN inhibition decreased cell proliferation and cell viability by promoting apoptosis in hormone-dependent breast and endometrial cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/16809439 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://purl.org/pav/importedOn 2016-02-19 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/dc/terms/created 2016-05-13T12:45:57+02:00 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v4.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP557327.RANedefjFp2qqSrXDRPIg3qtgNf6i_pdyRICCADo0IBS8 http://purl.org/pav/version v4.0.0.0 http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v4.0.0