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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#_4 http://www.w3.org/ns/prov#value 2 potential AP-1 binding sites located at positions -1000 to -994 and -943 to -937 was identified in the 248-bp fragment of the gonadotropin releasing hormone receptor (Gnrhr). A decrease in human GnRHR promoter activity was observed after GnRHa (GnRH agonists) treatment. GnRHa- and TPA-mediated decrease in the human GnRHR promoter activity was reversed by a specific protein kinase C inhibitor. These findings indicate that the activation of the PKC pathway is important in regulating the human GnRHR gene expression. EMSA studies with alphaT3-1 cells transfected with the Gnrhr reporter construct using anti-c-jun antibody demonstrated the binding of c-jun to the AP-1 binding site of the Gnrhr promoter. It was also demonstrated that mutation of the AP-1 binding site at -1000 to -994 abolished the GnRHa (GnRH agonists) induced inhibition. Thus, AP-1-binding site located at -1000 to -994 of the human GnRHR5'-flanking region has been identified to be involved in mediating the down-regulatory effect. http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11014215 http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11014215 http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#_4 http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ http://purl.org/dc/terms/created 2014-07-03T14:29:52.540+02:00 http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RANDJhyplvE-PkRvo-qvG_vYospabFy-O-q9Hp2U4jJTQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234