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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#_7 http://www.w3.org/ns/prov#value The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter region. Protein products of Per act together with Cry proteins to inhibit Per transcription, thus closing the autoregulatory feedback loop. We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 promoter through direct protein-protein interactions with Bmal1 and/or competition for E-box elements. http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12397359 http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12397359 http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#_7 http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo http://purl.org/dc/terms/created 2014-07-03T14:30:06.653+02:00 http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAN8urDsMxu6AcR8lDuZ0Hqpcw_s9THB7w6BA7We_CMDo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234