@prefix dc: <http://purl.org/dc/terms/> .
@prefix orcid: <http://orcid.org/> .
@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_head {
  this: np:hasAssertion dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_assertion;
    np:hasProvenance dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_provenance;
    np:hasPublicationInfo dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_assertion a np:Assertion .
  
  dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_provenance a np:Provenance .
  
  dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_assertion {
  miriam-gene:5604 a ncit:C16612 .
  
  lld:C0017638 a ncit:C7057 .
  
  dgn-gda:DGNdb9fbaef09b939fcb9f26ba4ff0827db sio:SIO_000628 miriam-gene:5604, lld:C0017638;
    a sio:SIO_001121 .
}

dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_provenance {
  dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_assertion dc:description
      "[We report here that: (a) in gliomas, [3H]TdR incorporation was enhanced by anti-Fas IgM monoclonal antibody CH-11 and conversely inhibited by anti-FasL monoclonal antibody NOK-2; (b) cross-linking of Fas with CH-11 drove both cell cycle progression and apoptosis as demonstrated by the induction of the S-G2 phase of DNA and RNA and fragmented nuclei; (c) phosphorylation of extracellular signal-regulated kinase (ERK), but not of c-Jun NH2-terminal kinase or p38, was induced by cross-linking of Fas; (d) a mitogen-activated protein kinase/ERK kinase 1 (MEK1) inhibitor PD98059 completely blocked CH-11-induced ERK phosphorylation as well as cell cycle progression without affecting induction of apoptosis; and (e) a broad-spectrum caspase inhibitor Z-Asp-CH2-DCB inhibited CH-11-induced ERK phosphorylation, cell cycle progression, and apoptosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:10749152;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP808842.RAN2NTH8TTu379x5TE602EovTPOQCprwNYy1GzmnsRsoo130_publicationInfo {
  this: dc:created "2014-10-02T12:40:16+02:00"^^xsd:dateTime;
    dc:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dc:rightsHolder dgn-void:IBIGroup;
    dc:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy orcid:0000-0001-5999-6269, orcid:0000-0002-7534-7661, orcid:0000-0002-9383-528X,
      orcid:0000-0003-0169-8159, orcid:0000-0003-1244-7654;
    pav:createdBy orcid:0000-0003-0169-8159;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}