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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#_3 http://www.w3.org/ns/prov#value We have shown that the transcription factors E2A and HEB associate with high affinity to these E-boxes. Moreover, we have identified pT alpha as a direct target of E2A-HEB heterodimers in immature thymocytes because they specifically occupy the enhancer in vivo. In these cells, pT alpha mRNA levels are determined by the presence of one or two functional E2A or HEB alleles. Furthermore, E2A/HEB transcriptional activity is repressed by heterodimerization with SCL, a transcription factor that is turned off in differentiating thymocytes exactly at a stage when pT alpha is up-regulated. http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12566462 http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12566462 http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#_3 http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw http://purl.org/dc/terms/created 2014-07-03T14:31:58.703+02:00 http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAN1WCo0HQgdpsjOMxmg8mp-8lF09LzEv-OhQmJcf0HMw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234