@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAN-lnqYbCk0n7n5iKq0QtfDetnt3b3Pt2tcnM-r1t4jg> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAN-lnqYbCk0n7n5iKq0QtfDetnt3b3Pt2tcnM-r1t4jg#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix do: <http://disease-ontology.org/term/DOID:> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
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    a go:0003824 .
  sub:_2 geneProductOf: hgnc:11822 ;
    a Protein: .
  sub:_3 geneProductOf: hgnc:11892 ;
    a Protein: .
  sub:_4 occursIn: do:1909 , species:9606 ;
    rdf:object sub:_3 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "cat(p(HGNC:TIMP3)) -> p(HGNC:TNF)" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "20131211" .
  sub:_5 dce:identifier "Landes Bioscience - TIMPs in Tumor Growth and Invasion" ;
    dce:title "Landes Bioscience - TIMPs in Tumor Growth and Invasion" ;
    dce:type "Other" .
  sub:_6 prov:value "TIMP-3 expressing stable colon carcinoma cell lines display reduced tumor growth, 199 and in these cells TIMP-3 overexpression resulted in apoptosis through stabilization of TNF-a receptors on the cell surface. 200 This suggests that individual TIMPs may modulate the levels of death proteins from the cell surface, as demonstrated by findings that shedding of FAS from the cell surface is mediated by MMP-induced cleavage and is inhibited by synthetic MMP inhibitors. 201" ;
    prov:wasQuotedFrom sub:_5 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource sub:_5 ;
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}
sub:pubinfo {
  this: dct:created "2014-07-03T14:31:28.589+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}