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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAMkSt9B_XKi7EoL3pt5xPfNbkEzgvF_NpoTOn2GY8ZRQ#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAMkSt9B_XKi7EoL3pt5xPfNbkEzgvF_NpoTOn2GY8ZRQ#_6 http://www.w3.org/ns/prov#value show a good clinical response to EGFR TKIs such as gefitinib, but they almost invariably develop drug resistance after an average of 12 months5. A secondary mutation in exon 20 (T790M) is found in about half of patients with a primary mutation that have grown resistant after an initial response to EGFR TKIs6–8. More recently, a new secondary mutation (D761Y) was found in a brain metastasis of a lung cancer initially responsive to gefitinib9. 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