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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#_7 http://www.w3.org/ns/prov#value Since alpha 2-macroglobulin is a binding protein for transforming growth factors-beta (TGF-beta), it was of interest to test whether the related protein, PZP, also binds to these growth-regulatory proteins. Using affinity-labelling methods, we demonstrate that PZP binds both TGF-beta 1 and TGF-beta 2 and that the binding characteristics are similar to those of the TGF-beta-alpha 2-macroglobulin interaction. Finally, we demonstrate that PZP inhibits the binding of TGF-beta 1 and TGF-beta 2 to their cell surface receptors. http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/7513640 http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/7513640 http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#_7 http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ http://purl.org/dc/terms/created 2014-07-03T14:33:44.480+02:00 http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAMPm1o0SP238csSqgRyjhUBez1oLGFPKWq_5JKRoTqAQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234