http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#Head http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#assertion http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#provenance http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#assertion http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_2 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8977 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_1 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=41472 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:caffeine) -| kin(p(HGNC:PIK3CD)) http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_4 http://www.w3.org/ns/prov#value We found that caffeine inhibits the in vitro lipid kinase of class I PI3Ks (IC(50) = 75 microm for p110 delta, 400 microm for p110 alpha and p110 beta, and 1 mm for p110 gamma), and theophylline has similar effects (IC(50) = 75 microm for p110 delta, 300 microm for p110 alpha, and 800 microm for p110 beta and p110 gamma) and also inhibits the alpha isoform of class II PI3K (PI3K-C2 alpha) (IC(50) approximately 400 microm). Surprisingly the triazoloquinazoline CGS15943 (9-chloro-2-(2-furyl)(1,2,d)triazolo(1,5-c)quinazolin-5-amine) also selectively inhibits p110 delta (IC(50) < 10 microm). http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12145276 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12145276 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#_4 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4 http://purl.org/dc/terms/created 2014-07-03T14:31:51.984+02:00 http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAMKj9_AMVxE5BBqQ64hN-zDRph3q_XpFYHpZhlcIRrb4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234