sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_6 ; pav:version "20131211" . sub:_5prov:value "The P13K/Akt signalling pathway results in aggressive proliferation and is activated in most tumors, including gastric adenocarcinoma [107-109]. The tumor suppressor gene, pten (phosphatase and tensin homolog on chromosome ten), inhibits P13K function. Loss of pten expression is associated with P13/Akt signalling activation in many tumors. MiR-19a binds pten in vitro, and overexpression of miR-19 in lymphomas correlates with reduced expression of the Pten protein, thus overexpression of miR-19 in tumors could represent an alternative mechanism of activation of the P13K/Akt signalling pathway [58]." ; prov:wasQuotedFrompubmed:19412438 . sub:_6rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:19412438 ; prov:wasDerivedFrombeldoc: , sub:_5 . }