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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#_3 http://www.w3.org/ns/prov#value pancreatic cancer cells are usually resistant to apoptosis mediated by intrinsic or extrinsic factors. bag-3 (bis, cair), which was identified as a bag-1-related protein, is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with bcl-2. in this study we analyzed bag-3 expression in human pancreatic cancer tissues and cell lines. bag-3 mrna was expressed at moderate to high levels in all pancreatic cancer samples, but at low levels in normal pancreas tissues. in situ hybridization and immunohistochemistry analysis revealed that bag-3 was present in the cancer cells within the pancreatic tumor mass. when bag-3 mrna was analyzed in other gastrointestinal cancers (hepatocellular carcinoma; esophageal, stomach and colon cancer), no difference was found from their corresponding normal controls. in pancreatic cancer cells, bag-3 mrna expression levels were strongly induced after heat stress, but not in response to members of the tumor necrosis factor (tnf)-alpha family (tnf-alpha, trail, fasl). these findings indicate that in pancreatic cancer, in contrast to other gastrointestinal malignancies, increased levels of bag-3 might function to block apoptosis. this characteristic of pancreatic cancer might contribute to its more aggressive growth behavior and poor responsiveness to treatment in vivo. in pancreatic cancer cells, bag-3 mrna expression levels were strongly induced after heat stress, but not in response to members of the tumor necrosis factor (tnf)-alpha family (tnf-alpha, trail, fasl). http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11513873 http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11513873 http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#_3 http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ http://purl.org/dc/terms/created 2014-07-03T14:29:57.893+02:00 http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAM6-WWIodNVeddtY8hFJBfoiG1Blq8M74hZ1OPIkxjFQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234