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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAM2Qf-eyUEjfzBa7fM0S3GFn2s6_SAo94taRXTyklpL0#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAM2Qf-eyUEjfzBa7fM0S3GFn2s6_SAo94taRXTyklpL0#_3 http://www.w3.org/ns/prov#value Therefore, we examined the expression of several genes important in lipid metabolism in ATMs from normal diet and high-fat diet mice. Apoe was downregulated in ATMs with high-fat diet. Expression of both adipocyte differentiation–related protein (Adfp) and peroxisome proliferator activation receptor-? (Pparg) were increased in high-fat diet ATMs (Fig. 4A). To determine the functional significance of these findings, we examined the lipid content of ATMs isolated from normal diet–and high-fat diet–fed animals by Nile Red staining. 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