sub:assertion {
  d:DB05465 v:identifier "DB05465" ;
    v:namespace "drugbank" ;
    v:uri "http://bio2rdf.org/drugbank:DB05465" ;
    v:x-identifiers.org <http://identifiers.org/drugbank/DB05465> ;
    dv:drugbank-id "DB05465" ;
    dv:x-bindingdb <http://bio2rdf.org/bindingdb:13535> ;
    dv:x-cas <http://bio2rdf.org/cas:> ;
    dv:x-chemspider <http://bio2rdf.org/chemspider:2302085> ;
    dv:x-pubchemcompound <http://bio2rdf.org/pubchem.compound:3038522> ;
    dct:description "MLN518 is a novel, oral, small molecule designed to inhibit type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and c-KIT. Tyrosine kinases are enzymes involved in several cellular processes and are known to be activated in cancer cells to drive tumor growth. AML patients with FLT3 mutations experience earlier disease relapse and shorter survival rates compared to patients without these mutations. Approximately 25 to 30 percent of all adult AML patients have a mutation of the FLT3 gene. The use of MLN518 to treat AML has been granted fast-track status by the U.S. Food and Drug Administration. Phase I/II trials are underway."@en ;
    dct:identifier "drugbank:DB05465" ;
    dct:title "MLN-518"@en ;
    a dv:Drug ;
    rdfs:label "MLN-518 [drugbank:DB05465]"@en ;
    rdfs:seeAlso <http://www.drugbank.ca/drugs/DB05465> .
}