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[Hypoxia, shortage in oxygen, greatly influences cellular phenotypes by altering the expression of specific genes, and is an important contributor to intra- and inter-tumor cell diversity as revealed by the pronounced but non-uniform expression of hypoxia-driven genes in solid tumors (reviewed in [Semenza GL.Targeting HIF-1 for cancer therapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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