sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_6 ; pav:version "1.4" . sub:_5prov:value "IL-1beta increased HK activity in both a time- and concentration-dependent manner: activity increased maximally by approximately 50% between 12 and 24 h with an apparent EC(50) of 3 pM. IL-1alpha mimicked, but did not augment, the effects of IL-1beta. Changes in HK activity were associated with both increased Glc metabolism and selective increases in HKII isoform abundance # Pubmed:gene: Proinflammatory interleukin-1 cytokines increase mesangial cell hexokinase activity and hexokinase II isoform abundance." ; prov:wasQuotedFrompubmed:15070811 . sub:_6rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:15070811 ; prov:wasDerivedFrombeldoc: , sub:_5 . }