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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#_5 http://www.w3.org/ns/prov#value Although it has been clearly established that negative feedback loops have a fundamental role in the regulation of epidermal growth factor receptor (EGFR) signalling in flies, their role in the regulation of mammalian EGFR has been inferred only recently from in vitro studies. Here, we report on the forced expression of RALT/MIG-6, a negative feedback regulator of ErbB receptors, in mouse skin. Conversely, knockdown of RALT by RNA interference enhanced ErbB mitogenic signalling. Thus, RALT behaves as a suppressor of EGFR signalling in mouse skin. http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16007071 http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16007071 http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#_5 http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY#pubinfo http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY http://purl.org/dc/terms/created 2014-07-03T14:32:47.339+02:00 http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RALm_3N5hM-nxb2XlzD6CYOMGWduUWUY_SE8UEkZg6csY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234