. . . . . . . . . . . . . . . . "p(HGNC:IFNG) -> kin(p(HGNC:JAK2))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "IFN-gamma-induced BAL1/BBAP transactivation requires JAK2 kinase and an intact IRF element. We next analyzed the downstream signaling molecules required for IFN-gamma-mediated BAL1/BBAP induction. For this reason, HEK293 cells were transfected with a luciferase reporter vector driven by the BAL1/BBAP minimal promoter (BAL1 109 458Luc) and treated with IFN-gamma in the presence or absence of the chemical JAK2 inhibitor AG490 (used at doses that specifically inhibit JAK2 kinase activity without nonspecific toxicity). AG490 inhibited IFNgamma-induced BAL1/BBAP promoter activity in a dose-dependent manner, directly implicating JAK2 and the associated STAT-1 and IRF transcription factors in this process (data not shown)." . . "Selventa" . . . . "2014-07-03T14:33:01.671+02:00"^^ . . .