sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "20131211" .
  sub:_5 prov:value "IFN-gamma-induced BAL1/BBAP transactivation requires JAK2 kinase and an intact IRF element. We next analyzed the downstream signaling molecules required for IFN-gamma-mediated BAL1/BBAP induction. For this reason, HEK293 cells were transfected with a luciferase reporter vector driven by the BAL1/BBAP minimal promoter (BAL1 109 458Luc) and treated with IFN-gamma in the presence or absence of the chemical JAK2 inhibitor AG490 (used at doses that specifically inhibit JAK2 kinase activity without nonspecific toxicity). AG490 inhibited IFNgamma-induced BAL1/BBAP promoter activity in a dose-dependent manner, directly implicating JAK2 and the associated STAT-1 and IRF transcription factors in this process (data not shown)." ;
    prov:wasQuotedFrom pubmed:16809771 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16809771 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}