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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RALc2V6hmZ0MmnbbXh3KzHK6mLc_miQiiuIG37ZpONltc#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RALc2V6hmZ0MmnbbXh3KzHK6mLc_miQiiuIG37ZpONltc#_4 http://www.w3.org/ns/prov#value Two other endothelial cell-specific receptors, called Tie-1 and Tie-2 (for \"tyrosine kinase with immunoglobulin- and EGF-like domains\") have been identified several years ago. Knock-out experiments in mice have suggested a role for these receptors in blood vessel maturation. The ligands for Tie-2 have only recently been discovered: angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) both bind Tie-2, but only the binding of Ang-1 results in signal transduction and regulation of blood vessel maturation (227). 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