sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Two other endothelial cell-specific receptors, called Tie-1 and Tie-2 (for \\\"tyrosine kinase with immunoglobulin- and EGF-like domains\\\") have been identified several years ago. Knock-out experiments in mice have suggested a role for these receptors in blood vessel maturation. The ligands for Tie-2 have only recently been discovered: angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) both bind Tie-2, but only the binding of Ang-1 results in signal transduction and regulation of blood vessel maturation (227). Therefore, Ang-2 is a natural antagonist of Ang-1 (146)." ;
    prov:wasQuotedFrom pubmed:11172729 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11172729 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}