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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#_2 http://www.w3.org/ns/prov#value Chymostatin (5-10 nmol(-1) site(-1) day(-1)) reduced granuloma-associated angiogenesis by 57.3 and 70.0%. RT-PCR analysis showed that rMCP-5 mRNA amounts were significantly reduced by rMCP-5 AS-ODN (1.25-2.5-5.0 nmol site(-1)) by 69.5, 72.5 and 81.8%. In parallel experiments, rMCP-5 AS-ODN (1.25, 2.5, 5.0 nmol site(-1)) strongly reduced granuloma weight (26.1, 45.0 and 56.3%) and haemoglobin content (22.2, 50.4, 62.03%), suggesting that the observed effect is mediated through an antisense mechanism. In conclusion, these data suggest that: (i) inhibition of mast cell mediators release may represent a novel strategy to modulate angiogenesis; (ii) among the chymase family, rMCP-5 is a key promoter of angiogenesis in the rat. http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15723097 http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15723097 http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#_2 http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs#pubinfo http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs http://purl.org/dc/terms/created 2014-07-03T14:30:32.601+02:00 http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RALZWurMUz-t8YQwYC38UeofPYuRxAGgtB7U3Bi3vtgPs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234